MOTS-C

MOTS-c is a small peptide (16 amino acids) encoded within the mitochondrial 12S rRNA region. It’s part of a group of “mitochondrial-derived peptides” (MDPs) that function as signaling molecules. Here’s a breakdown of its role:

🔬 Mechanism of Action

• Metabolic Regulation – MOTS-c promotes glucose uptake, increases insulin sensitivity, and shifts metabolism toward fat utilization.
• AMPK Activation – It activates the AMPK pathway, improving energy balance and mimicking some effects of exercise.
• Mitochondrial Function – Enhances mitochondrial efficiency and resilience under metabolic stress.
• Cellular Stress Response – Plays a role in protecting cells against oxidative stress and aging-related dysfunction.

💉 Clinical & Functional Benefits (based on studies and early clinical use)

• Improves insulin resistance and may help with prediabetes/Type 2 diabetes.
• Enhances exercise performance and endurance (sometimes called an “exercise mimetic”).
• Supports fat loss by promoting lipid metabolism.
• Potential anti-aging effects, improving muscle function and protecting against age-related decline.
• Investigated for roles in longevity, cardiovascular health, and obesity management.